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ҶƼƻƷ

ҶƼƻƿԷ¼ࣺ

1.1( TNF)׿

(1)(etanercept) TNF- (p75)-ںϵףûǾTNFϸTNF壬TNFԣﵽ֢Ч1998112ձ׼ʹԹؽڼǵһ׼TNF-׿

(2)Ӣ(infliximab) һǶ(75%+25%С)TNF-ĵ¡壬Ը׺ԵĽϿܵļĤϵTNF-ӶTNF-Ľϡ⣬infliximabͨͲϸɱ˱TNF-ϸ1999 11 10 ״λFDA ׼RA

(3)ľ(adalimumab)һֻ򵰰(IgG)¡壬ԿTNF-и߶ȵ׺Ժԣ׿TNF-ĽϣܽTNF-ϸ2002 12 31 ,ľFDA׼ƶһֻֿʪҩЧǷѵжضȻRAߡ

1.2 IL-1׿

ǰ (anakinra) һIL-1׿ҩûǾԵIL-1ĽϣӶֹڶ֯бIL-1ԡ

1.3 IL-6׿

Antiinterleukin-6 antibody(MRA)RAѪIL-6AI-6(slL-6R)ˮƽͼĻءMRAԴAL-6(IL-6R)ĵ¡壬ԵĤ1L-6ļԵIL-6RϣӶIL-6ܡ

1.4 BϸƼ

(Rituximab) һBϸCD20ӵǶϵ¡壬ĤԭCD20ϡBϸCD20ԭϺ߷λٽBϸܽ⡣

1.5 TϸƼ

(Abatacept) CTLA-4ϸ⹦IgG FcɵںϵףѡTϸFDA 2005l2׼AbataceptӦRA


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